Crossword clue: a defect or malformation; esp., a fissure of the iris supposed to be a persistent embryonic cleft.

The most common answer is coloboma (8 letters).

1 answer found in Letterora's clue database (Wikidata facts, Open Trivia DB, WordNet and Webster definitions — all licensed sources).

Possible answers

coloboma 8 letters web-def

A defect or malformation; esp., a fissure of the iris supposed to be a persistent embryonic cleft.