How many letters does the top answer for “physically and mentally fatigued” have?

The most common answer is aweary (6 letters).

Crossword clue: physically and mentally fatigued

2 answers found in Letterora's clue database (Wikidata facts, Open Trivia DB, WordNet and Webster definitions — all licensed sources).

aweary 6 letters wn-def

physically and mentally fatigued

weary 5 letters wn-def

exhaust or get tired through overuse or great strain or stress

mentally or physically unfit 50% similar → afflicted